Immunotherapy for SCLC include 4 kinds of drugs now.
name | company | type | trail |
Atezolizumab(Tecentriq) (阿特利珠单抗、泰圣奇) | Roche | PD-L1 | IMpower133 |
durvalumab (Imfinzi)(德瓦鲁单抗、度伐利尤单抗、英非凡) | AZ | PD-L1 | CASPIAN |
阿得贝利单抗 | 恒瑞 | PD-L1 | CAPSTONE-1 |
斯鲁利单抗 | 复宏汉霖 | PD-1 | ASTRUM |
- 斯鲁利单抗是唯一用于SCLC的免疫检查点抑制的PD-1药物。ASTRUM试验显示获得最长的OS,但临床试验设计存疑,且3级以上irAEs达到86%
- PD-L1相对副反应低,但SCLC总体缓解时间短,英非凡有较好的数据