4种已上市SCLC免疫药

Immunotherapy for SCLC include 4 kinds of drugs now.

namecompanytypetrail
Atezolizumab(Tecentriq) (阿特利珠单抗、泰圣奇)RochePD-L1IMpower133
durvalumab (Imfinzi)(德瓦鲁单抗、度伐利尤单抗、英非凡)AZPD-L1CASPIAN
阿得贝利单抗恒瑞PD-L1CAPSTONE-1
斯鲁利单抗复宏汉霖PD-1ASTRUM
已上市SCLC免疫药
  • 斯鲁利单抗是唯一用于SCLC的免疫检查点抑制的PD-1药物。ASTRUM试验显示获得最长的OS,但临床试验设计存疑,且3级以上irAEs达到86%
  • PD-L1相对副反应低,但SCLC总体缓解时间短,英非凡有较好的数据